PHENDIMETRAZINE is a weight loss medication. It is available with a prescription under several brand names – Bontril, Phendiet, Phenzene, Plegine.
Phendimetrazine is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an “anorectic” or “anorexigenic” drug.
Combined with a reduced calorie diet, it can help you reduce weight by decreasing your appetite. Generic phendimetrazine is available.
Phendimetrazine stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.

Phendimetrazine is used along with a doctor-approved, reduced-calorie diet, exercise, and behavior change program to help you lose weight.   It is used in people who are significantly overweight (obese) and have not been able to lose enough weight with diet and exercise alone.

The immediate-release formulation is available in 35 mg tablets and capsules. The sustained-release formulation is available in 105 mg capsules. Other brand or generic formulations may also be available.

Phendimetrazine is usually taken for only a few weeks at a time. It should not be taken with other appetite suppressants.
The possibility of serious side effects increases with longer use of this medication and use of this drug along with certain other diet drugs.

This medication may cause dependence, especially if it has been used regularly for an extended time or if it has been used in high doses. In such cases, withdrawal reactions (e.g., depression, severe tiredness) may occur if you suddenly stop this drug. To prevent withdrawal when stopping extended/regular treatment with this drug, gradually reduce the dosage as directed.
This medication may stop working well after you have been taking it for a while.

Phendimetrazine is usually taken once a day (sustained release formula) or two to three times daily (immediate-release formula) before meals on an empty stomach. Do not take phendimetrazine in the evening because it may cause insomnia. Do not crush, chew, or open any “once-daily” phendimetrazine tablets or capsules. Swallow them whole.