Weight loss diets

ACOMPLIA ( active ingredient in Acomplia is rimonabant) approved in the European Union as an adjunct to diet and exercise for the treatment of obese patients.
If approved in the United States, it is intended to be marketed under the name Zimulti.

Rimonabant, discovered and developed by French pharmaceutical company Sanofi-Synthelabo.

In Europe, it is indicated for use in conjunction with diet and exercise for patients with a body mass index
greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated risk factors, such as type 2
diabetes or dyslipidaemia.

Rimonabant acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle.
CB1 receptor blockade with ACOMPLIAН acts to decrease the overactivity of the endocannabinoid system (EC system). The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism.

In total more than 6800 patients were included in the Phase 2 and Phase 3 clinical studies. The patients included in the phase 3 trials followed a restrictive diet during the trial prescribed by a dietician and they were advised to increase their physical activity. Patients had a BMI GREATER-THAN OR EQUAL TO 30 kg/m2 or BMI >27 kg/m2 with hypertension and/or dyslipidemia at inclusion. Approximately 80% of the population were women, 87% Caucasian and 9% Black. Experience in patients over 75 years and Orientals/Asians was limited.
In clinical trials, over one year 33% of patients lost more than 10% of their initial bodyweight, with nearly two thirds of patients losing over 5%.
Most of the observed weight reduction was obtained within the first nine months of treatment. ACOMPLIA 20 mg was effective in maintaining weight loss up to two years. Weight loss at two years was 5.1 kg for patients who received ACOMPLIA 20 mg and 1.2 kg for placebo.
The effects on body weight appeared to be consistent among men and women. In the limited number of Black patients weight loss was less pronounced.

Method of administration
In adults, the recommended dosage is one 20 mg tablet daily to be taken in
the morning before breakfast.
The treatment should be introduced with a mildly reduced calorie diet.
The safety and efficacy of rimonabant have not been evaluated beyond 2 years.

Side Effects of Acomplia
Nausea, vomitting and other gastrointestinal disorders were relatively common side effects of taking Acomplia.
Disorders of the nervous system includes: headaches, faintness and feeling dizzy.
Psychiatric disorders Including: mood swings, anxiety, depression, irritability, sleep disorders and other similar disorders. If you already have a history of mental health disorders, it would be highly adviseable to mention this to your doctor before obtaining Acomplia.

Warnings and precautions
ACOMPLIA should be used with caution in patients over 75 years of age.
ACOMPLIA should be used with caution in patients with moderate hepatic impairment. ACOMPLIA should not be used in patients with severe hepatic impairment.
No dosage adjustment is required for patients with mild and moderate renal impairment. ACOMPLIA should not be used in patients with severe renal impairment.
ACOMPLIA is not recommended for use in children below age 18 due to a lack of data on efficacy and safety.

Rimonabant should be used with caution in combination with potent CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, ritonavir, telithromycin, clarithromycin, nefazodone)
Since ACOMPLIA tablets contain lactose, patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption, should not take ACOMPLIA.

ACOMPLIA Overdose
Experience with rimonabant in overdosage is limited. In a single-dose tolerability study, doses up to 300 mg were administered to a limited number of subjects with only minor symptoms reported. These included headache, euphoria, fatigue and insomnia. The pharmacokinetic profile demonstrates that a plateau in exposures is reached at 180 mg. There is no specific antidote for rimonabant; therefore, appropriate supportive measures should be initiated in case of overdose. Treatment should consist of the general measures employed in the management of overdoses, such as keeping airways unobstructed, monitoring cardiovascular function and general symptomatic and supportive measures.

Rimonabant may also be found to be effective in assisting some smokers to quit smoking. Sanofi-Aventis is
currently conducting studies to determine the possible value of rimonabant in smoking-cessation therapy.

Researchers report found that three diet drugs Xenical, Meridia and Acomplia (Acomplia is not sold in the United States, still hasn’t been approved for use in the United States) , will assist in weight loss, but there can be serious side effects and the weight loss isn’t all that great.

People who took the prescription drugs Xenical, Meridia and Acomplia registered lower blood pressure and cholesterol levels and reduced diabetes. For the 45 to 50-year-old study group, which had an average weight of 220 pounds, weight loss registered a little less than 11 pounds per person.

About 20 percent of those who took Meridia experienced side effects that included raised blood pressure and pulse rates, insomnia and nausea. Up to 30 percent of those who took Xenical had side effects that included unpleasant digestive and intestinal side effects.

About six percent of those who took Acomplia experienced mood disorders, a primary reason the drug didn’t receive FDA approval, the wire service reported.

Diet pills can help you to lose weight very quickly, but they should only be used when prescribed by a GP to patients who are clinically obese.

The diet pills can be few types:

Appetite Suppressants (Anorectics) diet pills

Used on a short term basis to combat obesity, usually when a monitored diet and exercise regime has been tried unsuccessfully.

A few of the most popular appetite suppressant diet pills:
• Adipex , Ionamin (Phentermine )
• Tenuate
• Prelu-2, Bontril (Phendimetrazine )
• Didrex (Benzphetamine )
• Meridia , Reductil ( Sibutramine )
• Acomplia (Rimonabant ) , also known as Riobant, Slimona, Rimoslim, and Zimulti
• Oxyntomodulin

this pills can sometimes have unwanted side effects such as heart valve damage.

Fat Blockers

a few of the most popular fat blocker diet pills:
• Trimspa
• Xenical (or Orlistat ) or Alli – a half-strength version of Xenical
• Chitosan Plus
• Cortipren
• NV
• Cortislim
• Zantrex

Xenical is the major prescription drug.
Most fat blockers are based on Chitosan, fat inhibitor.
The beauty of these drugs is that the user does not need to cut fatty foods or carbs from their diet.

Fat Burners

Fat Burners reduce the amount of fat stored in your body.

Diuretic pills

Not the most healthy way to lose weight. these drugs are supposed to work by reducing your excess body water.

and Placebos pills

Diet pills that contain nothing , just sugar or chalk etc. Placebos effect based on person’s beliefs and hopes in Magical Pills or diet supplement.

Some diet pills formerly contained ephedra until that ingredient was banned by the U.S. Food and Drug Administration.

Natural Weight Loss – Herbal Diet Pills

Hoodia , primary active ingredient is Hoodia gordonii (the African succulent plant )
Hoodia Gordonii is also availeble as weight loss pills

As any weight loss diet if you stop taking weight loss diet pills you may be subject to regaining all of the weight you lost. The best and safest way to lose weight and keep it off is through a well-balanced diet and regular exercise.